Cyproheptadine is a serotonin and histamine antagonist with property. It finds clinical application in stimulating the appetite and growth. The appetite stimulating effect of cyproheptadine is probably a consequence of serotonin antagonism. It antagonizes the satiety stimulating effects of serotonin on the satiety center. Weight gain has been observed with cyproheptadine can be attributed to an interference with regulation of the secretion of growth hormone.
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